Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients
Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cyt...
Saved in:
Main Authors: | , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/13859 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.13859 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.138592018-06-11T12:19:57Z Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients Pensri Saelee Ubol Chuensumran Sopit Wongkham Sunanta Chariyalertsak Danai Tiwawech Songsak Petmitr National Cancer Institute Thailand Suan Dusit University Khon Kaen University Mahidol University Biochemistry, Genetics and Molecular Biology Medicine Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cytokine signaling 1 gene (SOCS1) occurs in HCCs. Methylation specific-PCR assays were performed to identify the methylation status of SOCS1 in 29 tumors and their corresponding normal liver tissues. An abnormal methylation status was detected in 17 (59%), with a higher prevalence of aberrant SOCS1 methylation significantly correlating with HCC treated without chemotherapy (OR=0.04, 95%CI=0.01-0.31; P=0.001). This study suggests that epigenetic aberrant SOCS1 methylation may be a predictive marker for HCC patients. 2018-06-11T04:40:32Z 2018-06-11T04:40:32Z 2012-01-01 Article Asian Pacific Journal of Cancer Prevention. Vol.13, No.7 (2012), 3489-3493 10.7314/APJCP.2012.13.7.3489 2476762X 15137368 2-s2.0-84873628694 https://repository.li.mahidol.ac.th/handle/123456789/13859 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873628694&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Biochemistry, Genetics and Molecular Biology Medicine |
spellingShingle |
Biochemistry, Genetics and Molecular Biology Medicine Pensri Saelee Ubol Chuensumran Sopit Wongkham Sunanta Chariyalertsak Danai Tiwawech Songsak Petmitr Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients |
description |
Hepatocellular carcinoma (HCC), the most common primary hepatic tumor, is highly prevalent in the Asia-Pacific region, including Thailand. Many genetic and epigenetic alterations in HCC have been elucidated. The aim of this study was to determine whether aberrant methylation of the suppressor of cytokine signaling 1 gene (SOCS1) occurs in HCCs. Methylation specific-PCR assays were performed to identify the methylation status of SOCS1 in 29 tumors and their corresponding normal liver tissues. An abnormal methylation status was detected in 17 (59%), with a higher prevalence of aberrant SOCS1 methylation significantly correlating with HCC treated without chemotherapy (OR=0.04, 95%CI=0.01-0.31; P=0.001). This study suggests that epigenetic aberrant SOCS1 methylation may be a predictive marker for HCC patients. |
author2 |
National Cancer Institute Thailand |
author_facet |
National Cancer Institute Thailand Pensri Saelee Ubol Chuensumran Sopit Wongkham Sunanta Chariyalertsak Danai Tiwawech Songsak Petmitr |
format |
Article |
author |
Pensri Saelee Ubol Chuensumran Sopit Wongkham Sunanta Chariyalertsak Danai Tiwawech Songsak Petmitr |
author_sort |
Pensri Saelee |
title |
Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients |
title_short |
Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients |
title_full |
Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients |
title_fullStr |
Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients |
title_full_unstemmed |
Hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients |
title_sort |
hypermethylation of suppressor of cytokine signaling 1 in hepatocellular carcinoma patients |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/13859 |
_version_ |
1763493366781181952 |