Bacterial gene loss as a mechanism for gain of antimicrobial resistance

• Main Authors: M. E. Török, N. Chantratita, S. J. Peacock
• Other Authors: University of Cambridge
• Format: Review
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/14260
• Institution: Mahidol University

Acquisition of exogenous DNA by pathogenic bacteria represents the basis for much of the acquired antimicrobial resistance in pathogenic bacteria. A more extreme mechanism to avoid the effect of an antibiotic is to delete the drug target, although this would be predicted to be rare since drug target...