Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria

• Main Authors: Khin Maung Lwin, Aung Pyae Phyo, Joel Tarning, Warunee Hanpithakpong, Elizabeth A. Ashley, Sue J. Lee, Phaikyeong Cheah, Pratap Singhasivanon, Nicholas J. White, Niklas Lindegårdh, François Nosten
• Other Authors: Shoklo Malaria Research Unit
• Format: Article
• Published: 2018
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/14938
• Institution: Mahidol University

Intermittent preventive treatment (IPT) is increasingly used to reduce malaria morbidity and mortality in children and pregnant women. The efficacy of IPT depends on the pharmacokinetic and pharmacodynamic properties of the antimalarial drugs used. Healthy adult male volunteers whose occupation put...