Involvement of p53 and nuclear factor-kappaB signaling pathway for the induction of G1-phase cell cycle arrest of cholangiocarcinoma cell lines by isomorellin

• Main Authors: Chariya Hahnvajanawong, Supaluk Ketnimit, Kovit Pattanapanyasat, Natthinee Anantachoke, Banchob Sripa, Khosit Pinmai, Wunchana Seubwai, Vichai Reutrakul
• Other Authors: Khon Kaen University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15153
• Institution: Mahidol University

Cell cycle arrest is closely linked to apoptosis. Isomorellin - a caged xanthone isolated from Garcinia hanburyi - induced apoptosis in cholangiocarcinoma (CCA) cell lines. To elucidate potential anticancer mechanisms, we investigated the effects of isomorellin on the growth, cell cycle progression,...