Population pharmacokinetics of halofantrine in healthy volunteers and patients with symptomatic falciparum malaria

• Main Authors: Kerenaftali Klein, Leon Aarons, Feiko O. Ter Kuile, Francois Nosten, Nick J. White, Michael D. Edstein, Paktiya Teja-Isavadharm
• Other Authors: University of Queensland
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15154
• Institution: Mahidol University

Aims To investigate the population pharmacokinetics of the antimalarial halofantrine (HF) in healthy volunteers and patients with symptomatic falciparum malaria. Methods Healthy volunteer data were obtained from six volunteers who received three different doses of HF (250, 500 and 1000 mg) after an...