Extracellular heme enhances the antimalarial activity of artemisinin

• Main Authors: Sunanta Tangnitipong, Thitiporn Thaptimthong, Sirada Srihirun, Supeenun Unchern, Dusadee Kittikool, Rachanee Udomsangpetch, Nathawut Sibmooh
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15178

Artemisinin exerts the antimalarial activity through activation by heme. The hemolysis in malaria results in the elevated levels of plasma heme which may affect the activity of artemisinin. We hypothesized that the extracellular heme would potentiate the antimalarial activity of artemisinin. Hemin (...