Preparation and in vitro characterization of SN-38-loaded, self-forming polymeric depots as an injectable drug delivery system
This work describes the preparation and characterization of anticancer-loaded injectable polymeric depots that consisted of d,l-lactide (LA), ε-caprolactone (CL), and poly(ethylene glycol) (PEG) or [poly(ε-caprolactone)-random-poly(d,l-lactide)]-block-poly(ethylene glycol)-block-[poly(ε-caprolactone...
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| Main Authors: | , , , |
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| Format: | Article |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/15180 |
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| Institution: | Mahidol University |
| Summary: | This work describes the preparation and characterization of anticancer-loaded injectable polymeric depots that consisted of d,l-lactide (LA), ε-caprolactone (CL), and poly(ethylene glycol) (PEG) or [poly(ε-caprolactone)-random-poly(d,l-lactide)]-block-poly(ethylene glycol)-block-[poly(ε-caprolactone)-random-poly(d,l-lactide)] (PLEC) copolymers for malignant gliomas treatment. PLECs were polymerized with different percentages of LA to deliver 7-ethyl-10-hydroxycamptothecin (SN-38), a highly potent anticancer drug. SN-38-loaded depots could form directly in phosphate buffer saline with more than 98% encapsulation efficiency. The release rate of SN-38 from depots was found to depend on the amount of LA in PLECs, loading content of SN-38 in the depots, and depot weight. Encapsulation of SN-38 inside depots could enhance the stability of SN-38 where all of SN-38 released after 60 days was in an active form. Depots without SN-38 were evaluated as noncytotoxic against U-87MG, whereas SN-38-loaded depots showed cytotoxic effect as a function of concentration. © 2012 Wiley Periodicals, Inc. |
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