Paclitaxel delivery using carrier made from curcumin derivative: Synergism between carrier and the loaded drug for effective cancer treatment

• Main Authors: Kittima Amornwachirabodee, Khajeelak Chiablaem, Sumrit Wacharasindhu, Kriengsak Lirdprapamongkol, Jisnuson Svasti, Viwat Vchirawongkwin, Supason P. Wanichwecharungruang
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15183
• Institution: Mahidol University

To fully make use of the synergism between paclitaxel and curcumin (CUR) in cancer treatment, carrier made from CUR derivative was synthesized and used to deliver paclitaxel into cancer cells. The methoxylpolyethylene oxide-linked palmitate-modified curcumin (mPEO-CUR-PA) was synthesized and the obt...