Spleen in falciparum malaria: ultrastructural study.
An ultrastructural study was undertaken of the spleen of 13 year-old-boy who died of falciparum malaria. The spleen revealed the following: both parasitized and non-parasitized erythrocytes are phagocytosed in large numbers by macrophages, littoral and reticular cells. Blood congestion and trapping...
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th-mahidol.153792018-06-14T16:02:27Z Spleen in falciparum malaria: ultrastructural study. E. Pongponratn M. Riganti D. Bunnag T. Harinasuta Mahidol University Medicine An ultrastructural study was undertaken of the spleen of 13 year-old-boy who died of falciparum malaria. The spleen revealed the following: both parasitized and non-parasitized erythrocytes are phagocytosed in large numbers by macrophages, littoral and reticular cells. Blood congestion and trapping of parasitized erythrocytes are commonly seen in splenic sinusoids and cords. Erythrocytes forming rosette structure around immuno-presenting cells is observed. The results of this study provide evidence that the mechanisms underlying splenic host defence in malaria include both immunological and non-immunological interaction with erythrocytes. Splenic trapping of parasitized erythrocytes is an important defence mechanism and the phagocytosis of erythrocytes probably accounts for anaemia. 2018-06-14T09:02:27Z 2018-06-14T09:02:27Z 1987-12-01 Article The Southeast Asian journal of tropical medicine and public health. Vol.18, No.4 (1987), 491-501 01251562 2-s2.0-0023514089 https://repository.li.mahidol.ac.th/handle/123456789/15379 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023514089&origin=inward |
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Medicine E. Pongponratn M. Riganti D. Bunnag T. Harinasuta Spleen in falciparum malaria: ultrastructural study. |
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An ultrastructural study was undertaken of the spleen of 13 year-old-boy who died of falciparum malaria. The spleen revealed the following: both parasitized and non-parasitized erythrocytes are phagocytosed in large numbers by macrophages, littoral and reticular cells. Blood congestion and trapping of parasitized erythrocytes are commonly seen in splenic sinusoids and cords. Erythrocytes forming rosette structure around immuno-presenting cells is observed. The results of this study provide evidence that the mechanisms underlying splenic host defence in malaria include both immunological and non-immunological interaction with erythrocytes. Splenic trapping of parasitized erythrocytes is an important defence mechanism and the phagocytosis of erythrocytes probably accounts for anaemia. |
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Mahidol University |
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Mahidol University E. Pongponratn M. Riganti D. Bunnag T. Harinasuta |
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Article |
author |
E. Pongponratn M. Riganti D. Bunnag T. Harinasuta |
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E. Pongponratn |
title |
Spleen in falciparum malaria: ultrastructural study. |
title_short |
Spleen in falciparum malaria: ultrastructural study. |
title_full |
Spleen in falciparum malaria: ultrastructural study. |
title_fullStr |
Spleen in falciparum malaria: ultrastructural study. |
title_full_unstemmed |
Spleen in falciparum malaria: ultrastructural study. |
title_sort |
spleen in falciparum malaria: ultrastructural study. |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/15379 |
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1763495127436754944 |