Clinical importance of antimalarial pharmacokinetics
The efficacy of an antimalarial drug depends on its specific inhibitory or cidal activity on a given species and strain of a malaria parasite. It also depends on pharmacokinetic considerations such as the speed of absorption, concentration of drug in plasma or in infected erythrocytes, distribution...
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th-mahidol.156792018-06-14T16:11:30Z Clinical importance of antimalarial pharmacokinetics J. Karbwang N. J. White Mahidol University Pharmacology, Toxicology and Pharmaceutics The efficacy of an antimalarial drug depends on its specific inhibitory or cidal activity on a given species and strain of a malaria parasite. It also depends on pharmacokinetic considerations such as the speed of absorption, concentration of drug in plasma or in infected erythrocytes, distribution in tissues, clearance by metabolism and renal elimination and pharmacodynamic considerations such as toxicity. Recommendations on dosage regimens for antimalaria treatment and prophylaxis should be based on pharmacokinetic and pharmacodynamic studies performed in appropriate populations (i.e. both in volunteers and in children, adults and pregnant women with both uncomplicated and severe malaria). 2018-06-14T09:11:30Z 2018-06-14T09:11:30Z 1988-01-01 Article Asia Pacific Journal of Pharmacology. Vol.3, No.3 (1988), 181-189 02179687 2-s2.0-0023807742 https://repository.li.mahidol.ac.th/handle/123456789/15679 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023807742&origin=inward |
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Pharmacology, Toxicology and Pharmaceutics J. Karbwang N. J. White Clinical importance of antimalarial pharmacokinetics |
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The efficacy of an antimalarial drug depends on its specific inhibitory or cidal activity on a given species and strain of a malaria parasite. It also depends on pharmacokinetic considerations such as the speed of absorption, concentration of drug in plasma or in infected erythrocytes, distribution in tissues, clearance by metabolism and renal elimination and pharmacodynamic considerations such as toxicity. Recommendations on dosage regimens for antimalaria treatment and prophylaxis should be based on pharmacokinetic and pharmacodynamic studies performed in appropriate populations (i.e. both in volunteers and in children, adults and pregnant women with both uncomplicated and severe malaria). |
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Mahidol University |
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Mahidol University J. Karbwang N. J. White |
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J. Karbwang N. J. White |
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J. Karbwang |
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Clinical importance of antimalarial pharmacokinetics |
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Clinical importance of antimalarial pharmacokinetics |
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Clinical importance of antimalarial pharmacokinetics |
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Clinical importance of antimalarial pharmacokinetics |
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Clinical importance of antimalarial pharmacokinetics |
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clinical importance of antimalarial pharmacokinetics |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/15679 |
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