Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type

Associations between HLA‐DR/DQ phenotypes and immune responses to the circumsporozoite (CS) protein of the human malaria parasite, Plasmodium falciparum, were investigated in Thai adults. The frequency of DR and DQ types did not differ between 15 high antibody responders and 16 antibody non‐responde...

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Main Authors:	A. E. Brown, D. Chandanayingyong, S. V. Fuggle, H. K. Webster
Other Authors:	Armed Forces Research Institute of Medical Sciences, Thailand
Format:	Article
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Medicine
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/15732
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Institution:	Mahidol University

id	th-mahidol.15732
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spelling	th-mahidol.157322018-06-14T16:17:01Z Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type A. E. Brown D. Chandanayingyong S. V. Fuggle H. K. Webster Armed Forces Research Institute of Medical Sciences, Thailand Mahidol University Nuffield Department of Clinical Medicine Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Medicine Associations between HLA‐DR/DQ phenotypes and immune responses to the circumsporozoite (CS) protein of the human malaria parasite, Plasmodium falciparum, were investigated in Thai adults. The frequency of DR and DQ types did not differ between 15 high antibody responders and 16 antibody non‐responders. Initial results which suggested that lymphocyte responses to a CS‐derived peptide (R32tet32) might be HLA‐DR associated were not confirmed by subsequent extension of the study. Thus, MHC restriction appears not to be a major factor in the frequently observed unresponsiveness of the immune system to the P. falciparum sporozoite. Based on these results, it is expected that MHC restriction will not be a major obstacle to the application of a malaria vaccine in outbred human populations. Copyright © 1989, Wiley Blackwell. All rights reserved 2018-06-14T09:13:12Z 2018-06-14T09:13:12Z 1989-01-01 Article Tissue Antigens. Vol.34, No.3 (1989), 200-204 10.1111/j.1399-0039.1989.tb01737.x 13990039 00012815 2-s2.0-0024467044 https://repository.li.mahidol.ac.th/handle/123456789/15732 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024467044&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Medicine
spellingShingle	Biochemistry, Genetics and Molecular Biology Immunology and Microbiology Medicine A. E. Brown D. Chandanayingyong S. V. Fuggle H. K. Webster Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type
description	Associations between HLA‐DR/DQ phenotypes and immune responses to the circumsporozoite (CS) protein of the human malaria parasite, Plasmodium falciparum, were investigated in Thai adults. The frequency of DR and DQ types did not differ between 15 high antibody responders and 16 antibody non‐responders. Initial results which suggested that lymphocyte responses to a CS‐derived peptide (R32tet32) might be HLA‐DR associated were not confirmed by subsequent extension of the study. Thus, MHC restriction appears not to be a major factor in the frequently observed unresponsiveness of the immune system to the P. falciparum sporozoite. Based on these results, it is expected that MHC restriction will not be a major obstacle to the application of a malaria vaccine in outbred human populations. Copyright © 1989, Wiley Blackwell. All rights reserved
author2	Armed Forces Research Institute of Medical Sciences, Thailand
author_facet	Armed Forces Research Institute of Medical Sciences, Thailand A. E. Brown D. Chandanayingyong S. V. Fuggle H. K. Webster
format	Article
author	A. E. Brown D. Chandanayingyong S. V. Fuggle H. K. Webster
author_sort	A. E. Brown
title	Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type
title_short	Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type
title_full	Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type
title_fullStr	Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type
title_full_unstemmed	Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type
title_sort	immune responses to the circumsporozoite protein of plasmodium falciparum in relation to hla‐dr type
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/15732
_version_	1763494074838417408

Immune responses to the circumsporozoite protein of Plasmodium falciparum in relation to HLA‐DR type

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