Combined oral contraceptives and liver cancer
A multi‐national, hospital‐based, case‐control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever u...
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th-mahidol.157332018-06-14T16:17:08Z Combined oral contraceptives and liver cancer Ramiro Molina Luis Martinez Oriana Salas Aifredo Dabancens Tao Yun Chen Zhi‐Heng Hu Yong‐Wei Alvaro Cuadros Nubia Aristizabal Baruch Modan Elaine Ron Esther Alfandary J. G. Mati Patrick Kenya Alfred Kungu D. Gatei Patrick A. Ibeziako A. A. Abioye T. A. Junaid Patrick U. Aghadiuno Ruben A. Apelo Julietta R. De LaCruz Jose Baens Benjamin D. Canlas Suporn Silpisornkosol Tieng Pardthaisong Boonlong Sivasomboom Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Sermsri Sindhvananda Suporn Koetsawang Duangdao Rachawat Orawan Kiriwat Nivat Chantarakul P. P. Anthony David B. Thomas Janet L. Stanford Roberta M. Ray Elizabeth A. Noonan Susan Holck Facultad de Medicina de la Universidad de Chile Shanghai Institute of Planned Parenthood Research Hospital Universitario Chaim Sheba Medical Center Israel University of Nairobi University of Ibadan University of the Philippines Manila Chiang Mai University Chulalongkorn University Mahidol University Exeter North Devon Health Authority Fred Hutchinson Cancer Research Center Organisation Mondiale de la Sante Biochemistry, Genetics and Molecular Biology Medicine A multi‐national, hospital‐based, case‐control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral contraceptives was estimated to be 0.71 (95% Cl 0.4–1.2). No consistent trend in risk with months of use or time since first or last use was observed. Separate analyses also revealed no association between use of combined oral contraceptives and hepatocellular carcinoma (RR = 0.60) or cholangiocarcinoma (RR = 1.22). Most women in this study came from areas in which hepatitis B is endemic and rates of liver cancer are relatively high, and in most cases use of oral contraceptives was of short duration. These results provide no evidence that short‐term use of oral contraceptives enhances risk of liver cancer in countries where the determinants of this disease are similar to those observed in the countries where this study was conducted. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company 2018-06-14T09:13:12Z 2018-06-14T09:13:12Z 1989-01-01 Article International Journal of Cancer. Vol.43, No.2 (1989), 254-259 10.1002/ijc.2910430215 10970215 00207136 2-s2.0-0024516673 https://repository.li.mahidol.ac.th/handle/123456789/15733 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024516673&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Ramiro Molina Luis Martinez Oriana Salas Aifredo Dabancens Tao Yun Chen Zhi‐Heng Hu Yong‐Wei Alvaro Cuadros Nubia Aristizabal Baruch Modan Elaine Ron Esther Alfandary J. G. Mati Patrick Kenya Alfred Kungu D. Gatei Patrick A. Ibeziako A. A. Abioye T. A. Junaid Patrick U. Aghadiuno Ruben A. Apelo Julietta R. De LaCruz Jose Baens Benjamin D. Canlas Suporn Silpisornkosol Tieng Pardthaisong Boonlong Sivasomboom Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Sermsri Sindhvananda Suporn Koetsawang Duangdao Rachawat Orawan Kiriwat Nivat Chantarakul P. P. Anthony David B. Thomas Janet L. Stanford Roberta M. Ray Elizabeth A. Noonan Susan Holck Combined oral contraceptives and liver cancer |
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A multi‐national, hospital‐based, case‐control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral contraceptives was estimated to be 0.71 (95% Cl 0.4–1.2). No consistent trend in risk with months of use or time since first or last use was observed. Separate analyses also revealed no association between use of combined oral contraceptives and hepatocellular carcinoma (RR = 0.60) or cholangiocarcinoma (RR = 1.22). Most women in this study came from areas in which hepatitis B is endemic and rates of liver cancer are relatively high, and in most cases use of oral contraceptives was of short duration. These results provide no evidence that short‐term use of oral contraceptives enhances risk of liver cancer in countries where the determinants of this disease are similar to those observed in the countries where this study was conducted. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company |
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Facultad de Medicina de la Universidad de Chile |
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Facultad de Medicina de la Universidad de Chile Ramiro Molina Luis Martinez Oriana Salas Aifredo Dabancens Tao Yun Chen Zhi‐Heng Hu Yong‐Wei Alvaro Cuadros Nubia Aristizabal Baruch Modan Elaine Ron Esther Alfandary J. G. Mati Patrick Kenya Alfred Kungu D. Gatei Patrick A. Ibeziako A. A. Abioye T. A. Junaid Patrick U. Aghadiuno Ruben A. Apelo Julietta R. De LaCruz Jose Baens Benjamin D. Canlas Suporn Silpisornkosol Tieng Pardthaisong Boonlong Sivasomboom Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Sermsri Sindhvananda Suporn Koetsawang Duangdao Rachawat Orawan Kiriwat Nivat Chantarakul P. P. Anthony David B. Thomas Janet L. Stanford Roberta M. Ray Elizabeth A. Noonan Susan Holck |
format |
Article |
author |
Ramiro Molina Luis Martinez Oriana Salas Aifredo Dabancens Tao Yun Chen Zhi‐Heng Hu Yong‐Wei Alvaro Cuadros Nubia Aristizabal Baruch Modan Elaine Ron Esther Alfandary J. G. Mati Patrick Kenya Alfred Kungu D. Gatei Patrick A. Ibeziako A. A. Abioye T. A. Junaid Patrick U. Aghadiuno Ruben A. Apelo Julietta R. De LaCruz Jose Baens Benjamin D. Canlas Suporn Silpisornkosol Tieng Pardthaisong Boonlong Sivasomboom Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Sermsri Sindhvananda Suporn Koetsawang Duangdao Rachawat Orawan Kiriwat Nivat Chantarakul P. P. Anthony David B. Thomas Janet L. Stanford Roberta M. Ray Elizabeth A. Noonan Susan Holck |
author_sort |
Ramiro Molina |
title |
Combined oral contraceptives and liver cancer |
title_short |
Combined oral contraceptives and liver cancer |
title_full |
Combined oral contraceptives and liver cancer |
title_fullStr |
Combined oral contraceptives and liver cancer |
title_full_unstemmed |
Combined oral contraceptives and liver cancer |
title_sort |
combined oral contraceptives and liver cancer |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/15733 |
_version_ |
1763494537631629312 |