Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors
Associations between breast cancer risk factors and histologic types of invasive breast carcinoma were studied in 2,728 patients. Lobular and tubular carcinomas occurred with increased relative frequency in most high‐risk groups. The proportion of these types increased with age to a maximum at 45–49...
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th-mahidol.157342018-06-14T16:17:08Z Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors H. Stalsberg D. B. Thomas E. A. Noonan G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabancens Chen Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R.La De Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Suporn Koetsawang Daungdao Rachawat Nivat Chantarakul S. Holck Universitetet i Tromso Fred Hutchinson Cancer Research Center The University of Sydney Facultad de Medicina de la Universidad de Chile Shanghai Institute of Planned Parenthood Research Hospital Universitario Academy of Sciences Chaim Sheba Medical Center Israel University of Nairobi Hospital General de Mexico University of the Philippines Manila Chiang Mai University Chulalongkorn University Mahidol University Organisation Mondiale de la Sante Development and Research Training in Human Reproduction Biochemistry, Genetics and Molecular Biology Medicine Associations between breast cancer risk factors and histologic types of invasive breast carcinoma were studied in 2,728 patients. Lobular and tubular carcinomas occurred with increased relative frequency in most high‐risk groups. The proportion of these types increased with age to a maximum at 45–49 years and decreased in the following decade. Significantly increased proportions of lobular and tubular carcinomas were also associated with high‐risk countries, prior benign breast biopsy, bilateral breast cancer, concurrent mammary dysplasia, high age at first live birth, never‐pregnant patients compared to those with a first live birth before age 20, private pay status, and length of education. Nonsignificant increases were associated with family history of breast cancer, less than 5 live births, less than 25 months total of breast feeding, use of oral contraceptives or IUD, and high occupational class. As a general trend, the higher the overall relative risk, the higher the proportion of lobular and tubular carcinomas. The occurrence of other histologic types also increased with increased breast cancer risk, but to a smaller degree than for lobular/tubular carcinomas. It is suggested that all hormonally related, socio‐economic and geographic risk factors exert their effect by selectively increasing the number of lobular cells at risk. Family history of breast cancer and age over 49 years did not follow the general trend of parallel increases in the proportion of lobular/tubular carcinomas and breast cancer risk, and may operate through other mechanisms. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company 2018-06-14T09:13:12Z 2018-06-14T09:13:12Z 1989-01-01 Article International Journal of Cancer. Vol.44, No.3 (1989), 399-409 10.1002/ijc.2910440304 10970215 00207136 2-s2.0-0024443956 https://repository.li.mahidol.ac.th/handle/123456789/15734 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0024443956&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine H. Stalsberg D. B. Thomas E. A. Noonan G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabancens Chen Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R.La De Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Suporn Koetsawang Daungdao Rachawat Nivat Chantarakul S. Holck Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors |
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Associations between breast cancer risk factors and histologic types of invasive breast carcinoma were studied in 2,728 patients. Lobular and tubular carcinomas occurred with increased relative frequency in most high‐risk groups. The proportion of these types increased with age to a maximum at 45–49 years and decreased in the following decade. Significantly increased proportions of lobular and tubular carcinomas were also associated with high‐risk countries, prior benign breast biopsy, bilateral breast cancer, concurrent mammary dysplasia, high age at first live birth, never‐pregnant patients compared to those with a first live birth before age 20, private pay status, and length of education. Nonsignificant increases were associated with family history of breast cancer, less than 5 live births, less than 25 months total of breast feeding, use of oral contraceptives or IUD, and high occupational class. As a general trend, the higher the overall relative risk, the higher the proportion of lobular and tubular carcinomas. The occurrence of other histologic types also increased with increased breast cancer risk, but to a smaller degree than for lobular/tubular carcinomas. It is suggested that all hormonally related, socio‐economic and geographic risk factors exert their effect by selectively increasing the number of lobular cells at risk. Family history of breast cancer and age over 49 years did not follow the general trend of parallel increases in the proportion of lobular/tubular carcinomas and breast cancer risk, and may operate through other mechanisms. Copyright © 1989 Wiley‐Liss, Inc., A Wiley Company |
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Universitetet i Tromso |
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Universitetet i Tromso H. Stalsberg D. B. Thomas E. A. Noonan G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabancens Chen Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R.La De Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Suporn Koetsawang Daungdao Rachawat Nivat Chantarakul S. Holck |
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Article |
author |
H. Stalsberg D. B. Thomas E. A. Noonan G. Berry R. Maclennan R. Shearman T. Jelihovsky J. Cooper Booth R. Molina L. Martinez O. Salas A. Dabancens Chen Zhiheng Tao Yun Hu Yong Wei A. Cuadros N. Aristizabal K. Ebeling P. Nishan D. Kunde B. Modan E. Ron E. Alfandary J. G. Mati P. Kenya A. Kungu D. Gatei H. Rodriguez Cuevas S. Benavides Salazar A. Palet P. Ontiveros R. A. Apelo J. R.La De Cruz J. Baens B. Javier Suporn Silpisornkosol Tieng Pardthaisong Nimit Martin Choti Theetranont Banpot Boosiri Supawat Chutivongse Pramuan Virutamasen Chansuda Wongsrichanalai Prasarn Jimakorn Suporn Koetsawang Daungdao Rachawat Nivat Chantarakul S. Holck |
author_sort |
H. Stalsberg |
title |
Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors |
title_short |
Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors |
title_full |
Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors |
title_fullStr |
Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors |
title_full_unstemmed |
Histologic types of breast carcinoma in relation to international variation and breast cancer risk factors |
title_sort |
histologic types of breast carcinoma in relation to international variation and breast cancer risk factors |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/15734 |
_version_ |
1763494075004092416 |