A multicentred phase III comparative study of two hormonal contraceptive preparations given once-a-month by intramuscular injection. II. The comparison of bleeding patterns

• Main Authors: World Health Organization, Task Force On Long-Acting Systemic Agents for Fertility Regulation, S. Said, W. Sadek, A. Kholeif, Suporn Koetsawang, Orawan Kiriwat, Surat Piboonmanee, R. Rivera, G. Alvarado, M. A. Juarez, S. Aquilar, R. Santiso, C. F. Contreras, L. F. Galichl, M. Guirola, M. G. Alzugaray, M. L. Hernandez, J. R. Gallarco, B. Affandi, S. S.I. Santoso, R. S. Samil, A. Kazi, E. S. Kononova, V. I. Alipov, R. Apelo, E. S. Bernardo, I. Benitez, T. Canto-de-Cetina, S. Cardenas, L. Polanco, L. Vera, M. C. Cravioto, L. Hernandez, J. L. Fuziwara, J. Garza-Flores, G. Perez-Palacios, G. Oropeza, E. Mota, E. Zavaleta, G. Benagiano, C. Bastianelli, A. Diaz Infante-Ibarra (deceased), C. J. Castelo, R. Jiminez, N. Perez-Arocha, J. Lang-Prieto, J. A. Casas-Fernandez, H. M. Perez-Paz (deceased), M. Perez, A. R. Hernandez, C. Bustillo Tur, L. Kovacs, S. Koloszar, S. Bassol, A. M. Trujillo, R. Guzman-Serani, E. Israel, C. d'Arcangues, B. Busca, P. E. Hall, D. Machin, A. Pinol, F. Schlagenhaft
• Other Authors: Development and Research Training in Human Reproduction
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15881
• Institution: Mahidol University

A multicentred Phase III clinical trial was conducted in 12 countries to compare HRP112 (depot-medroxyprogesterone acetate, 25 mg and estradiol cypionate, 5 mg) and HRP102 (norethisterone enantate, 50 mg and estradiol valerate, 5 mg) given every 28 days. Contraceptive efficacy and side-effects of bo...