Immunogenicity of liposome-associated oral cholera vaccine prepared from combined Vibrio cholerae antigens

• Main Authors: W. Chaicumpa, J. R. Parairo, R. C. New, E. Pongponratn, Y. Ruangkunaporn, P. Tapchaisri, M. Chongsa-nguan
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/15990

Liposomes were prepared from bovine brain sphingomyelin and cholesterol. They were reinforced by incorporation of osmium tetroxide to prevent their immediate degradation inside the host. Combined Vibrio cholerae antigens (lipopolysaccharide, crude cell-bound hemagglutinin and procholeragenoid) were...