Genetic analysis of candidate modifier polymorphisms in Hb E-β⁰-thalassemia patients

• Main Authors: Orapan Sripichai, Johanna Whitacre, Thongperm Munkongdee, Chutima Kumkhaek, Wattanan Makarasara, Pranee Winichagoon, Ken Abel, Andreas Braun, Suthat Fucharoen
• Other Authors: The Institute of Science and Technology for Research and Development, Mahidol University
• Format: Conference or Workshop Item
• Published: 2018
• Subjects: Arts and Humanities; Biochemistry, Genetics and Molecular Biology; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16251
• Institution: Mahidol University

Hemoglobin E (Hb E)-β-thalassemia patients display a range of clinical severities, from nearly asymptomatic to transfusion-dependent: thalassemia major. Given this clinical heterogeneity, additional genetic factors modifying disease severity remain to be discovered. Association studies are being con...