The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience
BACKGROUND. It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients. METHODS. The authors reviewed the records of 124 patients > 1 year of age at diagnosis of...
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th-mahidol.162562018-06-21T15:18:45Z The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience Lisa M. McGregor Bhaskar N. Rao Andrew M. Davidoff Catherine A. Billups Suradej Hongeng Victor M. Santana D. Ashley Hill Christine Fuller Wayne L. Furman St. Jude Children Research Hospital University of Tennessee Health Science Center Washington University School of Medicine in St. Louis Mahidol University Biochemistry, Genetics and Molecular Biology Medicine BACKGROUND. It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients. METHODS. The authors reviewed the records of 124 patients > 1 year of age at diagnosis of International Neuroblastoma Staging System Stage 4 neuroblastoma. The survival estimates of those who did and did not have a gross total resection (GTR) and of those who had initial versus delayed GTR were compared. Surgical complications were reviewed. RESULTS. The 5-year survival estimates were comparable for the 90 patients who had a GTR and the 17 who underwent surgery but did not have a GTR (29.9% ± 5.1% [standard error] vs. 29.4% ± 10.1%). The 7 patients who underwent GTR at the time of diagnosis had a higher 5-year survival estimate than the 83 patients who had a GTR after induction chemotherapy (83.3% ± 13.9% vs. 25.2% ± 5.0%) (P = 0.001). Five-year event-free survival estimates were similarly higher in the initial-GTR group (57.1% ± 18.7% vs. 14.5% ± 4.2%) (P = 0.002). These two groups did not differ significantly in age at diagnosis (P = 0.118), site of primary tumor (P = 0.34), MYCN amplification status (P = 1), serum lactate dehydrogenase activity at diagnosis (P = 0.34), or treatment protocol (P = 0.22). Twenty-two (21%) patients had a surgical complication. CONCLUSIONS. In this small cohort of patients with metastatic neuroblastoma, GTR at the time of diagnosis offered a survival benefit. Further prospective studies are warranted before this approach can be applied to all patients with metastatic neuroblastoma. © 2005 American Cancer Society. 2018-06-21T08:07:32Z 2018-06-21T08:07:32Z 2005-12-15 Review Cancer. Vol.104, No.12 (2005), 2837-2846 10.1002/cncr.21566 0008543X 2-s2.0-29144520567 https://repository.li.mahidol.ac.th/handle/123456789/16256 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=29144520567&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Lisa M. McGregor Bhaskar N. Rao Andrew M. Davidoff Catherine A. Billups Suradej Hongeng Victor M. Santana D. Ashley Hill Christine Fuller Wayne L. Furman The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience |
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BACKGROUND. It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients. METHODS. The authors reviewed the records of 124 patients > 1 year of age at diagnosis of International Neuroblastoma Staging System Stage 4 neuroblastoma. The survival estimates of those who did and did not have a gross total resection (GTR) and of those who had initial versus delayed GTR were compared. Surgical complications were reviewed. RESULTS. The 5-year survival estimates were comparable for the 90 patients who had a GTR and the 17 who underwent surgery but did not have a GTR (29.9% ± 5.1% [standard error] vs. 29.4% ± 10.1%). The 7 patients who underwent GTR at the time of diagnosis had a higher 5-year survival estimate than the 83 patients who had a GTR after induction chemotherapy (83.3% ± 13.9% vs. 25.2% ± 5.0%) (P = 0.001). Five-year event-free survival estimates were similarly higher in the initial-GTR group (57.1% ± 18.7% vs. 14.5% ± 4.2%) (P = 0.002). These two groups did not differ significantly in age at diagnosis (P = 0.118), site of primary tumor (P = 0.34), MYCN amplification status (P = 1), serum lactate dehydrogenase activity at diagnosis (P = 0.34), or treatment protocol (P = 0.22). Twenty-two (21%) patients had a surgical complication. CONCLUSIONS. In this small cohort of patients with metastatic neuroblastoma, GTR at the time of diagnosis offered a survival benefit. Further prospective studies are warranted before this approach can be applied to all patients with metastatic neuroblastoma. © 2005 American Cancer Society. |
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St. Jude Children Research Hospital |
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St. Jude Children Research Hospital Lisa M. McGregor Bhaskar N. Rao Andrew M. Davidoff Catherine A. Billups Suradej Hongeng Victor M. Santana D. Ashley Hill Christine Fuller Wayne L. Furman |
format |
Review |
author |
Lisa M. McGregor Bhaskar N. Rao Andrew M. Davidoff Catherine A. Billups Suradej Hongeng Victor M. Santana D. Ashley Hill Christine Fuller Wayne L. Furman |
author_sort |
Lisa M. McGregor |
title |
The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience |
title_short |
The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience |
title_full |
The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience |
title_fullStr |
The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience |
title_full_unstemmed |
The impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: The St. Jude children's research hospital experience |
title_sort |
impact of early resection of primary neuroblastoma on the survival of children older than 1 year of age with stage 4 disease: the st. jude children's research hospital experience |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/16256 |
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1763495701305622528 |