In vivo and in vitro studies of fetal hemoglobin induction by hydroxyurea in β-thalassemia/hemoglobin E patients

• Main Authors: Yuwadee Watanapokasin, Suporn Chuncharunee, Duangmanee Sanmund, Wantana Kongnium, Pranee Winichagoon, Griffin P. Rodgers, Suthat Fucharoen
• Other Authors: Srinakharinwirot University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16270
• Institution: Mahidol University

Objective. Some, but not all, β-thalassemia/hemoglobin E (β-thal/HbE) patients respond to hydroxyurea treatment. It would be helpful if patient responses to hydroxyurea could be screened in vitro to identify responders and nonresponders before beginning in vivo treatment. Materials and Methods. Thir...