The phosphorylation of phospholipase C-gamma1, Raf-1, MEK, and ERK1/2 induced by a conserved retroviral peptide

• Main Authors: Tian Xue Fan, Noorbibi K. Day, Voravich Luangwedchakarn, Yenhui Chang, Susumu Ikehara, Danica L. Lerner, Soichi Haraguchi
• Other Authors: University of South Florida St. Petersburg
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16282
• Institution: Mahidol University

A synthetic 17-amino acid peptide (CKS-17) homologous to a highly conserved region of human and animal retroviral transmembrane proteins has been found to exhibit suppressive properties for numerous immune functions. It has been shown that CKS-17 causes an imbalance of human types 1 and 2 cytokines...