3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: Is 3-NPA in some plants produced by endophytes?

• Main Authors: Porntep Chomcheon, Suthep Wiyakrutta, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Duangnate Isarangkul, Prasat Kittakoop
• Other Authors: Chulalongkorn University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16328
• Institution: Mahidol University

3-Nitropropionic acid (3-NPA, 1) was found in extracts of several strains of endophytic fungi. 3-NPA (1) exhibited potent antimycobacterial activity with the minimum inhibition concentration of 3.3 μM, but was inactive against NCI-H187, BC, KB, and Vero cell lines. Endophytes were found to produce h...