Interdependent recruitment of SAGA and Srb mediator by transcriptional activator Gcn4p

• Main Authors: Hongfang Qiu, Cuihua Hu, Fan Zhang, Jiunn Hwang Gwo, Mark J. Swanson, Cheunchit Boonchird, Alan G. Hinnebusch
• Other Authors: National Institute of Child Health and Human Development
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16347
• Institution: Mahidol University

Transcriptional activation by Gcn4p is enhanced by the coactivators SWI/SNF, SAGA, and Srb mediator, which stimulate recruitment of TATA binding protein (TBP) and polymerase II to target promoters. We show that wild-type recruitment of SAGA by Gcn4p is dependent on mediator but independent of SWI/SN...