A variant in the CD209 promoter is associated with severity of dengue disease

• Main Authors: Anavaj Sakuntabhai, Chairat Turbpaiboon, Isabelle Casadémont, Ampaiwan Chuansumrit, Tassanee Lowhnoo, Anna Kajaste-Rudnitski, Sita Mint Kalayanarooj, Kanchana Tangnararatchakit, Nattaya Tangthawornchaikul, Sirijit Vasanawathana, Wathanee Chaiyaratana, Pa Thai Yenchitsomanus, Prapat Suriyaphol, Panisadee Avirutnan, Kulkanya Chokephaibulkit, Fumihiko Matsuda, Sutee Yoksan, Yves Jacob, G. Mark Lathrop, Prida Malasit, Philippe Desprès, Cécile Julier
• Other Authors: Institut Pasteur, Paris
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16353
• Institution: Mahidol University

Dengue fever and dengue hemorrhagic fever are mosquitoborne viral diseases. Dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells. Here, we report strong association between a...