Mechanical ventilation induces alterations of the ubiquitin-proteasome pathway in the diaphragm

• Main Authors: Keith C. DeRuisseau, Andreas N. Kavazis, Melissa A. Deering, Darin J. Falk, Darin Van Gammeren, Tossaporn Yimlamai, George A. Ordway, Scott K. Powers
• Other Authors: University of Florida
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Health Professions; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16363
• Institution: Mahidol University

Prolonged mechanical ventilation (MV) results in diaphragmatic atrophy due, in part, to an increase in proteolysis. These experiments tested the hypothesis that MV-induced diaphragmatic proteolysis is accompanied by increased expression of key components of the ubiquitin-proteasome pathway (UPP). To...