Stoichiometric selection of tight-binding inhibitors by wild-type mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase
A simple method for screening combinatorial and other libraries of inhibitors of malarial (Plasmodium falciparum) dihydrofolate reductase (PfDHFR) has been developed, based on the affinities of the inhibitors with the enzyme. In the presence of limiting amounts of the enzyme, a number of inhibitors...
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Main Authors: | , , , , , |
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Format: | Article |
Published: |
2018
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Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/16449 |
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Institution: | Mahidol University |