Curdlan sulphate in human severe/cerebral Plasmodium falciparum malaria

• Main Authors: I. Havlik, S. Looareesuwan, S. Vannaphan, P. Wilairatana, S. Krudsood, P. E. Thuma, D. Kozbor, N. Watanabe, Y. Kaneko
• Other Authors: University of Witwatersrand
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16593
• Institution: Mahidol University

Preclinical studies have shown that curdlan sulphate (CRDS), a sulphated 1 → 3-β-D glucan, inhibits Plasmodium falciparum in vitro and down-modulates the immune response. A direct, non-specific effect on cytoadherence and rosetting may be predicted, as has been described with other sulphated polysac...