Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus

Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus

We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresist...

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Main Authors: Nottasorn Plipat, Gilat Livni, Heidi Bertram, Richard B. Thomson
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/16994
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spelling th-mahidol.169942018-06-21T15:28:10Z Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus Nottasorn Plipat Gilat Livni Heidi Bertram Richard B. Thomson Mahidol University Schneider Childrens Medical Center Israel Department of Pathology and Laboratory Medicine Northwestern University Feinberg School of Medicine Medicine We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure. Copyright © 2005, American Society for Microbiology. All Rights Reserved. 2018-06-21T08:28:10Z 2018-06-21T08:28:10Z 2005-05-01 Article Journal of Clinical Microbiology. Vol.43, No.5 (2005), 2494-2496 10.1128/JCM.43.5.2494-2496.2005 00951137 2-s2.0-18544374025 https://repository.li.mahidol.ac.th/handle/123456789/16994 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=18544374025&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Nottasorn Plipat
Gilat Livni
Heidi Bertram
Richard B. Thomson
Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
description We tested 109 unique, vancomycin-susceptible, methicillin-resistant Staphylococcus aureus (MRSA) strains for vancomycin heteroresistance by a selection method, i.e., step-wise exposure of large inoculums to increasing concentrations of vancomycin. Although no strains demonstrated stable heteroresistance, 81 strains (74%) demonstrated unstable heteroresistance. Unstable heteroresistance is common among clinical isolates of MRSA and may represent a cause of therapeutic failure. Copyright © 2005, American Society for Microbiology. All Rights Reserved.
author2 Mahidol University
author_facet Mahidol University
Nottasorn Plipat
Gilat Livni
Heidi Bertram
Richard B. Thomson
format Article
author Nottasorn Plipat
Gilat Livni
Heidi Bertram
Richard B. Thomson
author_sort Nottasorn Plipat
title Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
title_short Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
title_full Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
title_fullStr Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
title_full_unstemmed Unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant Staphylococcus aureus
title_sort unstable vancomycin heteroresistance is common among clinical isolates of methiciliin-resistant staphylococcus aureus
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/16994
_version_ 1763491470533197824

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