Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis
Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et aL, Proc. Natl. Acad. Sci. USA, 88:...
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th-mahidol.172372018-07-04T13:56:53Z Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis Hisaki Nagai Mathurose Ponglikitmongkol Yong Sung Kim Kenichi Matsubara Hiroaki Tsumura Mathurose Ponglikitmongkol Yong Sung Kim Osaka University Hiroshima University Faculty of Medicine Mahidol University Genetic Engineering Research Institute Biochemistry, Genetics and Molecular Biology Medicine Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et aL, Proc. Natl. Acad. Sci. USA, 88:9523–9527, 1991). About 2000 Notl restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor. © 1995, American Association for Cancer Research. All rights reserved. 2018-07-04T06:52:19Z 2018-07-04T06:52:19Z 1995-10-15 Article Cancer Research. Vol.55, No.20 (1995), 4549-4551 15387445 00085472 2-s2.0-0028875208 https://repository.li.mahidol.ac.th/handle/123456789/17237 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028875208&origin=inward |
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Biochemistry, Genetics and Molecular Biology Medicine Hisaki Nagai Mathurose Ponglikitmongkol Yong Sung Kim Kenichi Matsubara Hiroaki Tsumura Mathurose Ponglikitmongkol Yong Sung Kim Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis |
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Hepatoblastoma is a frequent embryonic tumor found in children. The mechanism of its formation and development remain unknown. We analyzed genomic DNA aberrations associated with three hepatoblastomas by means of restriction landmark genomic scanning (I. Hatada et aL, Proc. Natl. Acad. Sci. USA, 88:9523–9527, 1991). About 2000 Notl restriction landmarks were monitored in each of the hepatoblastomas, which revealed that the intensity of eight spots decreased in the tumor genome, suggesting allelic loss. Three of these spots were identical to those that decreased in human hepatocellular carcinomas. These results suggested that common, early events are involved in the genesis of the two types of liver tumor. © 1995, American Association for Cancer Research. All rights reserved. |
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Osaka University |
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Osaka University Hisaki Nagai Mathurose Ponglikitmongkol Yong Sung Kim Kenichi Matsubara Hiroaki Tsumura Mathurose Ponglikitmongkol Yong Sung Kim |
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Article |
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Hisaki Nagai Mathurose Ponglikitmongkol Yong Sung Kim Kenichi Matsubara Hiroaki Tsumura Mathurose Ponglikitmongkol Yong Sung Kim |
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Hisaki Nagai |
title |
Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis |
title_short |
Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis |
title_full |
Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis |
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Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis |
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Genomic Aberrations in Human Hepatoblastomas Detected by 2-Dimensional Gel Analysis |
title_sort |
genomic aberrations in human hepatoblastomas detected by 2-dimensional gel analysis |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/17237 |
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1763492330982080512 |