Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment

Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment

The postantibiotic effects (PAEs) of 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The β-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize...

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Main Authors: L. Walsh, M. D. Smith, V. Wuthiekanun, N. J. White
Other Authors: Mahidol University
Format: Article
Published: 2018
Subjects:
Medicine
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/17452
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spelling th-mahidol.174522018-07-04T14:02:59Z Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment L. Walsh M. D. Smith V. Wuthiekanun N. J. White Mahidol University Medicine Pharmacology, Toxicology and Pharmaceutics The postantibiotic effects (PAEs) of 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The β-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis. 2018-07-04T06:58:50Z 2018-07-04T06:58:50Z 1995-01-01 Article Antimicrobial Agents and Chemotherapy. Vol.39, No.10 (1995), 2356-2358 10.1128/AAC.39.10.2356 00664804 2-s2.0-0029147063 https://repository.li.mahidol.ac.th/handle/123456789/17452 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0029147063&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Medicine
Pharmacology, Toxicology and Pharmaceutics
L. Walsh
M. D. Smith
V. Wuthiekanun
N. J. White
Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment
description The postantibiotic effects (PAEs) of 16 antibiotics or antibiotic combinations currently used against Burkholderia (Pseudomonas) pseudomallei were determined. The β-lactams had zero PAEs, while the carbapenems and ciprofloxacin induced median PAEs of 1 and 5 h, respectively. These results emphasize the need to maintain antibiotic levels above inhibitory concentrations in blood throughout the dosing interval in cases of severe melioidosis.
author2 Mahidol University
author_facet Mahidol University
L. Walsh
M. D. Smith
V. Wuthiekanun
N. J. White
format Article
author L. Walsh
M. D. Smith
V. Wuthiekanun
N. J. White
author_sort L. Walsh
title Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment
title_short Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment
title_full Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment
title_fullStr Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment
title_full_unstemmed Postantibiotic effects and Burkholderia (Pseudomonas) pseudomallei: Evaluation of current treatment
title_sort postantibiotic effects and burkholderia (pseudomonas) pseudomallei: evaluation of current treatment
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/17452
_version_ 1763496440423776256

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