Intracerebroventricular injection of CCK reduces operant sugar intake in pigs

Intracerebroventricular injection of CCK reduces operant sugar intake in pigs

Pigs have a strong appetite for sugar solutions and readily learn to perform operant responses (pressing a panel with their snouts) to obtain glucose solution. Intracerebroventricular (ICV) injection of 1 μg CCK produced a significant (p < 0.01) reduction in the amount of glucose consumed compare...

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Main Authors: B. A. Baldwin, S. Sukhchai
Other Authors: The Babraham Institute
Format: Article
Published: 2018
Subjects:
Neuroscience
Psychology
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/17831
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spelling th-mahidol.178312018-07-04T14:35:33Z Intracerebroventricular injection of CCK reduces operant sugar intake in pigs B. A. Baldwin S. Sukhchai The Babraham Institute Mahidol University Neuroscience Psychology Pigs have a strong appetite for sugar solutions and readily learn to perform operant responses (pressing a panel with their snouts) to obtain glucose solution. Intracerebroventricular (ICV) injection of 1 μg CCK produced a significant (p < 0.01) reduction in the amount of glucose consumed compared with saline in the 30 min following injection. The reduction was a central effect as the same dose of CCK was ineffective given intravenously. The inhibition of intake was completely abolished by prior dosing with 100 μg of the CCKA receptor antagonist Devazepide given ICV. Devazepide itself had no effect on intake. The pig is a good experimental animal for the study of the regulation of sugar intake. 2018-07-04T07:34:14Z 2018-07-04T07:34:14Z 1996-01-01 Article Physiology and Behavior. Vol.60, No.1 (1996), 231-233 10.1016/0031-9384(95)02211-2 00319384 2-s2.0-0030183288 https://repository.li.mahidol.ac.th/handle/123456789/17831 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030183288&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Neuroscience
Psychology
spellingShingle Neuroscience
Psychology
B. A. Baldwin
S. Sukhchai
Intracerebroventricular injection of CCK reduces operant sugar intake in pigs
description Pigs have a strong appetite for sugar solutions and readily learn to perform operant responses (pressing a panel with their snouts) to obtain glucose solution. Intracerebroventricular (ICV) injection of 1 μg CCK produced a significant (p < 0.01) reduction in the amount of glucose consumed compared with saline in the 30 min following injection. The reduction was a central effect as the same dose of CCK was ineffective given intravenously. The inhibition of intake was completely abolished by prior dosing with 100 μg of the CCKA receptor antagonist Devazepide given ICV. Devazepide itself had no effect on intake. The pig is a good experimental animal for the study of the regulation of sugar intake.
author2 The Babraham Institute
author_facet The Babraham Institute
B. A. Baldwin
S. Sukhchai
format Article
author B. A. Baldwin
S. Sukhchai
author_sort B. A. Baldwin
title Intracerebroventricular injection of CCK reduces operant sugar intake in pigs
title_short Intracerebroventricular injection of CCK reduces operant sugar intake in pigs
title_full Intracerebroventricular injection of CCK reduces operant sugar intake in pigs
title_fullStr Intracerebroventricular injection of CCK reduces operant sugar intake in pigs
title_full_unstemmed Intracerebroventricular injection of CCK reduces operant sugar intake in pigs
title_sort intracerebroventricular injection of cck reduces operant sugar intake in pigs
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/17831
_version_ 1763492331515805696

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