Novel cytotoxic 1H-cyclopenta[b]benzofuran lignans from Aglaia elliptica

• Main Authors: Baoliang Cui, Heebyung Chai, Thawatchai Santisuk, Vichai Reutrakul, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn
• Other Authors: University of Illinois at Chicago
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/17875
• Institution: Mahidol University

Bioassay-guided fractionation of the stems and fruits of Aglaia elliptica using human oral epidermoid carcinoma (KB) cells, led to the isolation of five cyclopenta[b]benzofurans, constituted by methyl rocaglate (1) and four novel compounds (2-5), along with three known dammarane triterpenoids. Compo...