Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes

• Main Authors: Rocío Foncea, Monica Andersson, Albert Ketterman, Vicky Blakesley, Mario Sapag-Hagar, Peter H. Sugden, Derek LeRoith, Sergio Lavandero
• Other Authors: Universidad de Chile
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/17887
• Institution: Mahidol University

In response to insulin-like growth factor-I (IGF-I), neonatal rat cardiac myocytes exhibit a hypertrophic response. The elucidation of the IGF- I signal transduction system in these cells remains unknown. We show here that cardiac myocytes present a single class of high affinity receptors (12,446 ±...