A novel mechanism of aberrant pre-mRNA splicing in humans

• Main Authors: Joy D. Cogan, Melissa A. Prince, Somsong Lekhakula, Sarah Bundey, Aree Futrakul, Eleanor M.S. McCarthy, John A. Phillips
• Other Authors: Vanderbilt University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/17894
• Institution: Mahidol University

Eukaryotic pre-mRNA splicing is regulated by consensus sequences at the intron boundaries and branch site. Recently, Sirand-Pugnet at al. reported the importance of an additional intronic sequence, an (A/U)GGG repeat in chicken β-tropomyosin that is a binding site for a protein required for spliceos...