A pharmacogenetic study of trimethylaminuria in orientals
A study of the metabolism of trimethylamine was carried out in 103 healthy Thai volunteers (70 men anti 33 women) and it was found that under normal dietary conditions 84-100% of trimethylamine was excreted in the urine in its N-oxide form. Five propositi living in different parts of the country wer...
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th-mahidol.179102018-07-04T14:55:31Z A pharmacogenetic study of trimethylaminuria in orientals Amnuay Thithapandha Mahidol University Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics A study of the metabolism of trimethylamine was carried out in 103 healthy Thai volunteers (70 men anti 33 women) and it was found that under normal dietary conditions 84-100% of trimethylamine was excreted in the urine in its N-oxide form. Five propositi living in different parts of the country were identified as having deficiency in the N-oxidation of this tertiary amine, because they excreted only 8-35% of this chemical as trimethylamine N-oxide. This metabolic defect was also confirmed by the results of an oral trimethylamine (600 mg) challenge experiment in which all five propositi were found to excrete an even smaller percentage of trimethylamine trimethylamine N-oxide in their urine. The results of a study of the families of the two proband individuals, as well as those members of their preceding generations under normal dietary conditions, are consistent with the view that the disorder or metabolic defect is inherited in a Mendelian fashion as an autosomal recessive trait, similar to that reported for white Caucasian subjects. 2018-07-04T07:41:12Z 2018-07-04T07:41:12Z 1997-01-01 Article Pharmacogenetics. Vol.7, No.6 (1997), 497-501 10.1097/00008571-199712000-00008 0960314X 2-s2.0-0030707609 https://repository.li.mahidol.ac.th/handle/123456789/17910 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0030707609&origin=inward |
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Biochemistry, Genetics and Molecular Biology Pharmacology, Toxicology and Pharmaceutics Amnuay Thithapandha A pharmacogenetic study of trimethylaminuria in orientals |
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A study of the metabolism of trimethylamine was carried out in 103 healthy Thai volunteers (70 men anti 33 women) and it was found that under normal dietary conditions 84-100% of trimethylamine was excreted in the urine in its N-oxide form. Five propositi living in different parts of the country were identified as having deficiency in the N-oxidation of this tertiary amine, because they excreted only 8-35% of this chemical as trimethylamine N-oxide. This metabolic defect was also confirmed by the results of an oral trimethylamine (600 mg) challenge experiment in which all five propositi were found to excrete an even smaller percentage of trimethylamine trimethylamine N-oxide in their urine. The results of a study of the families of the two proband individuals, as well as those members of their preceding generations under normal dietary conditions, are consistent with the view that the disorder or metabolic defect is inherited in a Mendelian fashion as an autosomal recessive trait, similar to that reported for white Caucasian subjects. |
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Mahidol University |
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Mahidol University Amnuay Thithapandha |
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Article |
author |
Amnuay Thithapandha |
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Amnuay Thithapandha |
title |
A pharmacogenetic study of trimethylaminuria in orientals |
title_short |
A pharmacogenetic study of trimethylaminuria in orientals |
title_full |
A pharmacogenetic study of trimethylaminuria in orientals |
title_fullStr |
A pharmacogenetic study of trimethylaminuria in orientals |
title_full_unstemmed |
A pharmacogenetic study of trimethylaminuria in orientals |
title_sort |
pharmacogenetic study of trimethylaminuria in orientals |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/17910 |
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