Prognostic factors among 130 patients with osteosarcoma
One hundred thirty patients with high grade osteosarcoma were enrolled in a randomized prospective multidisciplinary treatment that included intraarterial chemotherapy, local irradiation, limb salvage surgery, and prophylactic whole lung irradiation. The patients were evaluated to stage the prognost...
Saved in:
Main Authors: | , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/18020 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.18020 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.180202018-07-04T14:46:09Z Prognostic factors among 130 patients with osteosarcoma Lucksana Pochanugool Thanya Subhadharaphandou Montana Dhanachai Phongjan Hathirat Daungjai Sangthawan Ratana Pirabul Suporn Onsanit Naiyana Pornpipatpong Mahidol University Faculty of Medicine, Ramathibodi Hospital, Mahidol University Medicine One hundred thirty patients with high grade osteosarcoma were enrolled in a randomized prospective multidisciplinary treatment that included intraarterial chemotherapy, local irradiation, limb salvage surgery, and prophylactic whole lung irradiation. The patients were evaluated to stage the prognostic factors. In a multivariate analysis, a minimal level of serum lactic acid dehydrogenase less than 300 IU/L showed a significant prognostic value. The history of trauma before diagnosis of disease, local irradiation of the affected site, histologic response to preoperative multidisciplinary therapy, and prophylactic whole lung irradiation were associated with significantly better prognosis in the log rank test. Patient age, site of the primary tumor, presentation of fracture, pathologic subtype, signs and symptoms, serum alkaline phosphatase level, and erythrocyte sedimentation rate were not found to be prognostic factors. The 9-year survival rate of the whole group was 55%. 2018-07-04T07:46:09Z 2018-07-04T07:46:09Z 1997-12-01 Article Clinical Orthopaedics and Related Research. No.345 (1997), 206-214 0009921X 2-s2.0-0031440411 https://repository.li.mahidol.ac.th/handle/123456789/18020 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031440411&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Medicine |
spellingShingle |
Medicine Lucksana Pochanugool Thanya Subhadharaphandou Montana Dhanachai Phongjan Hathirat Daungjai Sangthawan Ratana Pirabul Suporn Onsanit Naiyana Pornpipatpong Prognostic factors among 130 patients with osteosarcoma |
description |
One hundred thirty patients with high grade osteosarcoma were enrolled in a randomized prospective multidisciplinary treatment that included intraarterial chemotherapy, local irradiation, limb salvage surgery, and prophylactic whole lung irradiation. The patients were evaluated to stage the prognostic factors. In a multivariate analysis, a minimal level of serum lactic acid dehydrogenase less than 300 IU/L showed a significant prognostic value. The history of trauma before diagnosis of disease, local irradiation of the affected site, histologic response to preoperative multidisciplinary therapy, and prophylactic whole lung irradiation were associated with significantly better prognosis in the log rank test. Patient age, site of the primary tumor, presentation of fracture, pathologic subtype, signs and symptoms, serum alkaline phosphatase level, and erythrocyte sedimentation rate were not found to be prognostic factors. The 9-year survival rate of the whole group was 55%. |
author2 |
Mahidol University |
author_facet |
Mahidol University Lucksana Pochanugool Thanya Subhadharaphandou Montana Dhanachai Phongjan Hathirat Daungjai Sangthawan Ratana Pirabul Suporn Onsanit Naiyana Pornpipatpong |
format |
Article |
author |
Lucksana Pochanugool Thanya Subhadharaphandou Montana Dhanachai Phongjan Hathirat Daungjai Sangthawan Ratana Pirabul Suporn Onsanit Naiyana Pornpipatpong |
author_sort |
Lucksana Pochanugool |
title |
Prognostic factors among 130 patients with osteosarcoma |
title_short |
Prognostic factors among 130 patients with osteosarcoma |
title_full |
Prognostic factors among 130 patients with osteosarcoma |
title_fullStr |
Prognostic factors among 130 patients with osteosarcoma |
title_full_unstemmed |
Prognostic factors among 130 patients with osteosarcoma |
title_sort |
prognostic factors among 130 patients with osteosarcoma |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/18020 |
_version_ |
1763497845369864192 |