Hypoglycemic and hypolipidemic effects of a water extract of Pandanus odorus Ridl. Roots in streptozotocin-diabetic rats

• Main Authors: P. Peungvicha, S. S. Thirawarapan, H. Watanabe
• Other Authors: Mahidol University
• Format: Conference or Workshop Item
• Published: 2018
• Subjects: Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18226

Plasma glucose and total lipid levels in normal and streptozotocin-diabetic rats were determined after oral administration of a water extract of Pandanus odorus Ridl. root. The oral administration of the water extract at doses of 0.25, 0.5 and 1 g kg-1produced a significant hypoglycemic effect in the intravenous glucose tolerance test and the adrenaline hyperglycemic test. Plasma non-esterified fatty acids were significantly decreased after 1 and 2 hours of single oral administration of the Pandanus extract at doses of 0.25 and 0.5 g kg-1. Plasma cholesterol and triglyceride were also significantly decreased by the extract after once daily oral administration of Pandanus extract at a dose of 0.5 g kg-1for 7 days. These results suggest that a water extract of Pandanus odorus has hypoglycemic and hypolipidemic effects in streptozotocin-diabetic rats.