Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species
Glutathione transferases (GST) are an ancient superfamily comprising a large number of paralogous proteins in a single organism. This multiplicity of GSTs has allowed the copies to diverge for neofunctionalization with proposed roles ranging from detoxication and oxidative stress response to invol...
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th-mahidol.18532023-04-12T15:23:32Z Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species Chonticha Saisawang Ketterman, Albert J. Mahidol University. Institute of Molecular Biosciences Micro-Plasticity As Illustrated Evolution of Glutathione 12 Drosophila Species Open Access article Glutathione transferases (GST) are an ancient superfamily comprising a large number of paralogous proteins in a single organism. This multiplicity of GSTs has allowed the copies to diverge for neofunctionalization with proposed roles ranging from detoxication and oxidative stress response to involvement in signal transduction cascades. We performed a comparative genomic analysis using FlyBase annotations and Drosophila melanogaster GST sequences as templates to further annotate the GST orthologs in the 12 Drosophila sequenced genomes. We found that GST genes in the Drosophila subgenera have undergone repeated local duplications followed by transposition, inversion, and micro-rearrangements of these copies. The colinearity and orientations of the orthologous GST genes appear to be unique in many of the species which suggests that genomic rearrangement events have occurred multiple times during speciation. The high microplasticity of the genomes appears to have a functional contribution utilized for evolution of this gene family. 2015-03-07T04:36:42Z 2017-04-25T03:40:58Z 2015-03-07T04:36:42Z 2017-04-25T03:40:58Z 2015-03-07 2014 Article PLOS ONE. Vol.9, No.10 (2014), 1-16 10.1371/journal.pone.0109518 https://repository.li.mahidol.ac.th/handle/123456789/1853 eng Mahidol University application/pdf |
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Micro-Plasticity As Illustrated Evolution of Glutathione 12 Drosophila Species Open Access article |
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Micro-Plasticity As Illustrated Evolution of Glutathione 12 Drosophila Species Open Access article Chonticha Saisawang Ketterman, Albert J. Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species |
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Glutathione transferases (GST) are an ancient superfamily comprising a large number of paralogous proteins in a single
organism. This multiplicity of GSTs has allowed the copies to diverge for neofunctionalization with proposed roles ranging
from detoxication and oxidative stress response to involvement in signal transduction cascades. We performed a
comparative genomic analysis using FlyBase annotations and Drosophila melanogaster GST sequences as templates to
further annotate the GST orthologs in the 12 Drosophila sequenced genomes. We found that GST genes in the Drosophila
subgenera have undergone repeated local duplications followed by transposition, inversion, and micro-rearrangements of
these copies. The colinearity and orientations of the orthologous GST genes appear to be unique in many of the species
which suggests that genomic rearrangement events have occurred multiple times during speciation. The high microplasticity
of the genomes appears to have a functional contribution utilized for evolution of this gene family. |
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Mahidol University. Institute of Molecular Biosciences |
author_facet |
Mahidol University. Institute of Molecular Biosciences Chonticha Saisawang Ketterman, Albert J. |
format |
Article |
author |
Chonticha Saisawang Ketterman, Albert J. |
author_sort |
Chonticha Saisawang |
title |
Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species |
title_short |
Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species |
title_full |
Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species |
title_fullStr |
Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species |
title_full_unstemmed |
Micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 Drosophila species |
title_sort |
micro-plasticity of genomes as illustrated by the evolution of glutathione transferases in 12 drosophila species |
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2015 |
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https://repository.li.mahidol.ac.th/handle/123456789/1853 |
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1781413848223318016 |