Renal tubular function in β-thalassemia

Studies of the renal involvement in thalassemic syndromes have been varied and few. This study was designed to define the renal abnormalities associated with β-thalassemia and to correlate the renal findings with clinical parameters. One hundred and four β-thalassemic children with various disease s...

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Main Authors: Achra Sumboonnanonda, Prida Malasit, Voravarn S. Tanphaichitr, Sompong Ong-ajyooth, Sunthorn Sunthornchart, Sa Nga Pattanakitsakul, Siripan Petrarat, Amara Assateerawatt, Arun Vongjirad
Other Authors: Mahidol University
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Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/18592
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spelling th-mahidol.185922018-07-04T15:16:24Z Renal tubular function in β-thalassemia Achra Sumboonnanonda Prida Malasit Voravarn S. Tanphaichitr Sompong Ong-ajyooth Sunthorn Sunthornchart Sa Nga Pattanakitsakul Siripan Petrarat Amara Assateerawatt Arun Vongjirad Mahidol University Medicine Studies of the renal involvement in thalassemic syndromes have been varied and few. This study was designed to define the renal abnormalities associated with β-thalassemia and to correlate the renal findings with clinical parameters. One hundred and four β-thalassemic children with various disease severity were studied. The patients were divided into three groups: 48 with severe anemia [hematocrit (Hct) < 25%], 31 on a hypertransfusion program and desferrioxamine treatment, and 25 with moderate anemia (Hct > 25%). The results were compared with 15 normal children. Significantly higher levels of proteinuria and low molecular weight proteinuria were found in all patients compared with normal children. Aminoaciduria was detected in one-third of patients. Thalassemic patients had significantly lower morning urine osmolarity, higher urine N-acetyl-β-D-glucoseminidase and malondialdehyde (MDA, an indicator of lipid peroxidation). Patients with severe anemia had significantly higher low-molecular weight proteinuria and MDA, and lower urine osmolarity than those with moderate anemia. Our data confirmed the high frequency of renal abnormalities in P-thalassemia patients and indicated some degree of proximal tubular dysfunction. Severity of the abnormalities correlated with the degree of anemia and were least severe in patients on hypertransfusion and desferrioxamine therapy. This suggested that the damage might be caused by anemia and increased oxidation induced by excess iron deposits. 2018-07-04T08:16:24Z 2018-07-04T08:16:24Z 1998-01-01 Article Pediatric Nephrology. Vol.12, No.4 (1998), 280-283 10.1007/s004670050453 0931041X 2-s2.0-0031800233 https://repository.li.mahidol.ac.th/handle/123456789/18592 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0031800233&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Medicine
spellingShingle Medicine
Achra Sumboonnanonda
Prida Malasit
Voravarn S. Tanphaichitr
Sompong Ong-ajyooth
Sunthorn Sunthornchart
Sa Nga Pattanakitsakul
Siripan Petrarat
Amara Assateerawatt
Arun Vongjirad
Renal tubular function in β-thalassemia
description Studies of the renal involvement in thalassemic syndromes have been varied and few. This study was designed to define the renal abnormalities associated with β-thalassemia and to correlate the renal findings with clinical parameters. One hundred and four β-thalassemic children with various disease severity were studied. The patients were divided into three groups: 48 with severe anemia [hematocrit (Hct) < 25%], 31 on a hypertransfusion program and desferrioxamine treatment, and 25 with moderate anemia (Hct > 25%). The results were compared with 15 normal children. Significantly higher levels of proteinuria and low molecular weight proteinuria were found in all patients compared with normal children. Aminoaciduria was detected in one-third of patients. Thalassemic patients had significantly lower morning urine osmolarity, higher urine N-acetyl-β-D-glucoseminidase and malondialdehyde (MDA, an indicator of lipid peroxidation). Patients with severe anemia had significantly higher low-molecular weight proteinuria and MDA, and lower urine osmolarity than those with moderate anemia. Our data confirmed the high frequency of renal abnormalities in P-thalassemia patients and indicated some degree of proximal tubular dysfunction. Severity of the abnormalities correlated with the degree of anemia and were least severe in patients on hypertransfusion and desferrioxamine therapy. This suggested that the damage might be caused by anemia and increased oxidation induced by excess iron deposits.
author2 Mahidol University
author_facet Mahidol University
Achra Sumboonnanonda
Prida Malasit
Voravarn S. Tanphaichitr
Sompong Ong-ajyooth
Sunthorn Sunthornchart
Sa Nga Pattanakitsakul
Siripan Petrarat
Amara Assateerawatt
Arun Vongjirad
format Article
author Achra Sumboonnanonda
Prida Malasit
Voravarn S. Tanphaichitr
Sompong Ong-ajyooth
Sunthorn Sunthornchart
Sa Nga Pattanakitsakul
Siripan Petrarat
Amara Assateerawatt
Arun Vongjirad
author_sort Achra Sumboonnanonda
title Renal tubular function in β-thalassemia
title_short Renal tubular function in β-thalassemia
title_full Renal tubular function in β-thalassemia
title_fullStr Renal tubular function in β-thalassemia
title_full_unstemmed Renal tubular function in β-thalassemia
title_sort renal tubular function in β-thalassemia
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/18592
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