A genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolates

• Main Authors: Karthikeyan Ganesan, Napawan Ponmee, Lei Jiang, Joseph W. Fowble, John White, Sumalee Kamchonwongpaisan, Yongyuth Yuthavong, Prapon Wilairat, Pradipsinh K. Rathod
• Other Authors: University of Washington, Seattle
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18837
• Institution: Mahidol University

Genome sequences of Plasmodium falciparum allow for global analysis of drug responses to antimalarial agents. It was of interest to learn how DNA microarrays may be used to study drug action in malaria parasites. In one large, tightly controlled study involving 123 microarray hybridizations between...