High-resolution melting curve analysis for genotyping of common SNP in MTHFR gene using fixed-cell suspension

• Main Authors: Thivaratana Sinthuwiwat, Phanasit Poowasanpetch, Angsana Wongngamrungroj, Somying Promso, Chirayu Auewarakul, Sean Mooney, Chintana Tocharoentanaphol
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18848
• Institution: Mahidol University

Genetic variation in MTHFR might explain the interindividual differences in both therapeutic and toxic responses to the treatment of cancer and rheumatoid arthritis with methotrexate, and can be involved in the sensitivity of developing diseases like cancer and congenital anomalies. We investigated...