Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05

Four new dimeric spiro-azaplilones, cochliodones A-D (1-4), two new azaphliones, chaetoviridines E and F (5 and 6), a new epi-chaetoviridin A (7), together with five known compounds, chaetoviridin A (8), ergosterol (9), chaetochalasin A (10), 24(R)-5α,8α-epidioxyergosta-6-22-diene-3β-ol (11), and er...

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Main Authors:	Nutchanat Phonkerd, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Kasem Soytong, Samran Prabpai, Palangpon Kongsearee
Other Authors:	Khon Kaen University
Format:	Article
Published:	2018
Subjects:	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
Online Access:	https://repository.li.mahidol.ac.th/handle/123456789/18855
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Institution:	Mahidol University

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spelling	th-mahidol.188552018-07-12T09:50:20Z Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05 Nutchanat Phonkerd Somdej Kanokmedhakul Kwanjai Kanokmedhakul Kasem Soytong Samran Prabpai Palangpon Kongsearee Khon Kaen University King Mongkut's Institute of Technology Ladkrabang Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Four new dimeric spiro-azaplilones, cochliodones A-D (1-4), two new azaphliones, chaetoviridines E and F (5 and 6), a new epi-chaetoviridin A (7), together with five known compounds, chaetoviridin A (8), ergosterol (9), chaetochalasin A (10), 24(R)-5α,8α-epidioxyergosta-6-22-diene-3β-ol (11), and ergosterol-β-d-glucoside (12) were isolated from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05. Structures and stereochemistry of the atropisomers 1-3 were determined by single-crystal X-ray diffraction analysis. Compounds 5, 10, and 11 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, 6, 10, and 11 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the KB, BC1, and NCI-H187 cell lines. © 2008 Elsevier Ltd. All rights reserved. 2018-07-12T02:17:11Z 2018-07-12T02:17:11Z 2008-09-29 Article Tetrahedron. Vol.64, No.40 (2008), 9636-9645 10.1016/j.tet.2008.07.040 00404020 2-s2.0-49549092692 https://repository.li.mahidol.ac.th/handle/123456789/18855 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=49549092692&origin=inward
institution	Mahidol University
building	Mahidol University Library
continent	Asia
country	Thailand Thailand
content_provider	Mahidol University Library
collection	Mahidol University Institutional Repository
topic	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics
spellingShingle	Biochemistry, Genetics and Molecular Biology Chemistry Pharmacology, Toxicology and Pharmaceutics Nutchanat Phonkerd Somdej Kanokmedhakul Kwanjai Kanokmedhakul Kasem Soytong Samran Prabpai Palangpon Kongsearee Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
description	Four new dimeric spiro-azaplilones, cochliodones A-D (1-4), two new azaphliones, chaetoviridines E and F (5 and 6), a new epi-chaetoviridin A (7), together with five known compounds, chaetoviridin A (8), ergosterol (9), chaetochalasin A (10), 24(R)-5α,8α-epidioxyergosta-6-22-diene-3β-ol (11), and ergosterol-β-d-glucoside (12) were isolated from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05. Structures and stereochemistry of the atropisomers 1-3 were determined by single-crystal X-ray diffraction analysis. Compounds 5, 10, and 11 exhibited antimalarial activity against Plasmodium falciparum, while 3, 5, 6, 10, and 11 showed antimycobacterial activity against Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the KB, BC1, and NCI-H187 cell lines. © 2008 Elsevier Ltd. All rights reserved.
author2	Khon Kaen University
author_facet	Khon Kaen University Nutchanat Phonkerd Somdej Kanokmedhakul Kwanjai Kanokmedhakul Kasem Soytong Samran Prabpai Palangpon Kongsearee
format	Article
author	Nutchanat Phonkerd Somdej Kanokmedhakul Kwanjai Kanokmedhakul Kasem Soytong Samran Prabpai Palangpon Kongsearee
author_sort	Nutchanat Phonkerd
title	Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
title_short	Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
title_full	Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
title_fullStr	Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
title_full_unstemmed	Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05
title_sort	bis-spiro-azaphilones and azaphilones from the fungi chaetomium cochliodes vth01 and c. cochliodes cth05
publishDate	2018
url	https://repository.li.mahidol.ac.th/handle/123456789/18855
_version_	1763487766530752512

Bis-spiro-azaphilones and azaphilones from the fungi Chaetomium cochliodes VTh01 and C. cochliodes CTh05

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