Dependence of reactive oxygen species and FLICE inhibitory protein on Lipofectamine-induced apoptosis in human lung epithelial cells

• Main Authors: Lalana Kongkaneramit, Narong Sarisuta, Neelam Azad, Yongju Lu, Anand Krishnan V. Iyer, Liying Wang, Yon Rojanasakul
• Other Authors: West Virginia University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18913
• Institution: Mahidol University

Cationic liposomes such as Lipofectamine (LF) are widely used as nonviral gene delivery vectors; however, their clinical application is limited by their cytotoxicity. These agents have been shown to induce apoptosis as the primary mode of cell death, but their mechanism of action is not well underst...