Prolactin directly enhances bone turnover by raising osteoblast-expressed receptor activator of nuclear factor κB ligand/osteoprotegerin ratio

• Main Authors: Dutmanee Seriwatanachai, Kanogwun Thongchote, Narattaphol Charoenphandhu, Jantarima Pandaranandaka, Kukiat Tudpor, Jarinthorn Teerapornpuntakit, Tuangporn Suthiphongchai, Nateetip Krishnamra
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18963

Hyperprolactinemia leads to high bone turnover as a result of enhanced bone formation and resorption. Although its osteopenic effect has long been explained as hyperprolactinemia-induced hypogonadism, identified prolactin (PRL) receptors in osteoblasts suggested a possible direct action of PRL on bo...