Trishomocubane amino acid as a β-turn scaffold

• Main Authors: Fernando Albericio, Per I. Arvidson, Krishna Bisetty, Ernest Giralt, Thavendran Govender, Samuel Jali, Palangpon Kongsaeree, Hendrik G. Kruger, Samran Prabpai
• Other Authors: Universitat de Barcelona
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18979
• Institution: Mahidol University

The synthesis and X-ray structure of two diasteriomeric heptapeptides [Ac-Ala-Ala-Ala-(R/S)-Cage-Ala-Ala-Ala-NH2] with a trishomocubane amino acid as a β-turn scaffold are reported. The amino acid was synthesized as a racemate and two diastereomeric peptides were obtained. The two peptides were sepa...