β-amyloid 25-35 peptide reduces the expression of glutamine transporter SAT1 in cultured cortical neurons

• Main Authors: Doungjai Buntup, Øivind Skare, Tom Tallak Solbu, Farrukh A. Chaudhry, Jon Storm-Mathisen, Wipawan Thangnipon
• Other Authors: The Institute of Science and Technology for Research and Development, Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18980
• Institution: Mahidol University

β-Amyloid (Aβ) peptides may cause malfunction and death of neurons in Alzheimer's disease. We investigated the effect of Aβ on key transporters of amino acid neurotransmission in cells cultured from rat cerebral cortex. The cultures were treated with Aβ(25-35) at 3 and 10 μM for 12 and 24 h fol...