Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales

Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3- methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl) -7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)-hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the...

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Main Authors: Vilailak Prachyawarakorn, Chulabhorn Mahidol, Sanya Sureram, Suwannee Sangpetsiripan, Suthep Wiyakrutta, Somsak Ruchirawat, Prasat Kittakoop
Other Authors: Chulabhorn Research Institute
Format: Article
Published: 2018
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Online Access:https://repository.li.mahidol.ac.th/handle/123456789/19010
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spelling th-mahidol.190102018-07-12T09:52:02Z Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales Vilailak Prachyawarakorn Chulabhorn Mahidol Sanya Sureram Suwannee Sangpetsiripan Suthep Wiyakrutta Somsak Ruchirawat Prasat Kittakoop Chulabhorn Research Institute Chulabhorn Graduate Institute Mahidol University The Institute of Science and Technology for Research and Development, Mahidol University Biochemistry, Genetics and Molecular Biology Chemistry Medicine Pharmacology, Toxicology and Pharmaceutics Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3- methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl) -7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)-hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1,3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 μg/mL. © Georg Thieme Verlag KG Stuttgart. 2018-07-12T02:20:42Z 2018-07-12T02:20:42Z 2008-01-01 Article Planta Medica. Vol.74, No.1 (2008), 69-72 10.1055/s-2007-993783 00320943 2-s2.0-39149083695 https://repository.li.mahidol.ac.th/handle/123456789/19010 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=39149083695&origin=inward
institution Mahidol University
building Mahidol University Library
continent Asia
country Thailand
Thailand
content_provider Mahidol University Library
collection Mahidol University Institutional Repository
topic Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
spellingShingle Biochemistry, Genetics and Molecular Biology
Chemistry
Medicine
Pharmacology, Toxicology and Pharmaceutics
Vilailak Prachyawarakorn
Chulabhorn Mahidol
Sanya Sureram
Suwannee Sangpetsiripan
Suthep Wiyakrutta
Somsak Ruchirawat
Prasat Kittakoop
Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
description Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3- methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl) -7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)-hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1,3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 μg/mL. © Georg Thieme Verlag KG Stuttgart.
author2 Chulabhorn Research Institute
author_facet Chulabhorn Research Institute
Vilailak Prachyawarakorn
Chulabhorn Mahidol
Sanya Sureram
Suwannee Sangpetsiripan
Suthep Wiyakrutta
Somsak Ruchirawat
Prasat Kittakoop
format Article
author Vilailak Prachyawarakorn
Chulabhorn Mahidol
Sanya Sureram
Suwannee Sangpetsiripan
Suthep Wiyakrutta
Somsak Ruchirawat
Prasat Kittakoop
author_sort Vilailak Prachyawarakorn
title Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
title_short Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
title_full Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
title_fullStr Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
title_full_unstemmed Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
title_sort diketopiperazines and phthalides from a marine derived fungus of the order pleosporales
publishDate 2018
url https://repository.li.mahidol.ac.th/handle/123456789/19010
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