Diketopiperazines and phthalides from a marine derived fungus of the order pleosporales

• Main Authors: Vilailak Prachyawarakorn, Chulabhorn Mahidol, Sanya Sureram, Suwannee Sangpetsiripan, Suthep Wiyakrutta, Somsak Ruchirawat, Prasat Kittakoop
• Other Authors: Chulabhorn Research Institute
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19010
• Institution: Mahidol University

Five metabolites, (Z)-6-benzylidene-3-hydroxymethyl-1,4-dimethyl-3- methylsulfanylpiperazine-2,5-dione (1), (3S,3′R)-3-(3′-hydroxybutyl) -7-methoxyphthalide (2), (S)-3-butyl-7-methoxyphthalide (3), (3R,6R)-bisdethiodi(methylthio)-hyalodendrin (4), and bis-N-norgliovictin (5), were isolated from the culture broth of the marine derived fungus of the order Pleosporales strain CRIF2. Compounds 1 and 2 are new fungal metabolites, while 3 was isolated for the first time as a natural product. Compounds 1,3, and 4 exhibited only weak cytotoxic activity, while 5 was inactive at 50 μg/mL. © Georg Thieme Verlag KG Stuttgart.