Plasmodium vivax trophozoites insensitive to chloroquine

• Main Authors: Wesley W. Sharrock, Rossarin Suwanarusk, Usa Lek-Uthai, Michael D. Edstein, Varakorn Kosaisavee, Thomas Travers, Anchalee Jaidee, Kanlaya Sriprawat, Ric N. Price, François Nosten, Bruce Russell
• Other Authors: Menzies School of Health Research
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19311
• Institution: Mahidol University

Background. Plasmodium vivax is a major cause of malaria and is still primarily treated with chloroquine. Chloroquine inhibits the polymerization of haem to inert haemozoin. Free haem monomers are thought to catalyze oxidative damage to the Plasmodium spp. trophozoite, the stage when haemoglobin cat...