High-dose primaquine regimens against relapse of Plasmodium vivax malaria

• Main Authors: Srivicha Krudsood, Noppadon Tangpukdee, Polrat Wilairatana, Nantaporn Phophak, J. Kevin Baird, Gary M. Brittenham, Sornchai Looareesuwan
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/19333

Plasmodium vivax causes debilitating but usually non-lethal malaria in most of Asia and South America. Prevention of relapse after otherwise effective therapy for the acute attack requires a standard daily dose of primaquine administered over 14 days. This regimen has < 90% efficacy in Thailand,...