Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report
Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments wi...
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th-mahidol.193472018-07-12T09:44:33Z Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report Marcus J. Rijken Rose McGready Machteld E. Boel Marion Barends Stephane Proux Mupawjay Pimanpanarak Pratap Singhasivanon François Nosten Shoklo Malaria Research Unit Mahidol University Immunology and Microbiology Medicine Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4). Copyright © 2008 by The American Society of Tropical Medicine and Hygiene. 2018-07-12T02:31:07Z 2018-07-12T02:31:07Z 2008-04-01 Article American Journal of Tropical Medicine and Hygiene. Vol.78, No.4 (2008), 543-545 00029637 2-s2.0-45349085248 https://repository.li.mahidol.ac.th/handle/123456789/19347 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=45349085248&origin=inward |
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Immunology and Microbiology Medicine Marcus J. Rijken Rose McGready Machteld E. Boel Marion Barends Stephane Proux Mupawjay Pimanpanarak Pratap Singhasivanon François Nosten Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report |
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Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4). Copyright © 2008 by The American Society of Tropical Medicine and Hygiene. |
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Shoklo Malaria Research Unit |
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Shoklo Malaria Research Unit Marcus J. Rijken Rose McGready Machteld E. Boel Marion Barends Stephane Proux Mupawjay Pimanpanarak Pratap Singhasivanon François Nosten |
format |
Article |
author |
Marcus J. Rijken Rose McGready Machteld E. Boel Marion Barends Stephane Proux Mupawjay Pimanpanarak Pratap Singhasivanon François Nosten |
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Marcus J. Rijken |
title |
Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report |
title_short |
Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report |
title_full |
Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report |
title_fullStr |
Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report |
title_full_unstemmed |
Short report: Dihydroartemisinin - Piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: A preliminary report |
title_sort |
short report: dihydroartemisinin - piperaquine rescue treatment of multidrug-resistant plasmodium falciparum malaria in pregnancy: a preliminary report |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/19347 |
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1763489387752980480 |