How antimalarial drug resistance affects post-treatment prophylaxis
Slowly eliminated antimalarial drugs suppress malaria reinfections for a period of time determined by the dose, the pharmacokinetic properties of the drug, and the susceptibility of the infecting parasites. This effect is called post-treatment prophylaxis (PTP). The clinical benefits of preventing r...
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th-mahidol.193572018-07-12T09:45:00Z How antimalarial drug resistance affects post-treatment prophylaxis Nicholas J. White Mahidol University University of Oxford Immunology and Microbiology Medicine Slowly eliminated antimalarial drugs suppress malaria reinfections for a period of time determined by the dose, the pharmacokinetic properties of the drug, and the susceptibility of the infecting parasites. This effect is called post-treatment prophylaxis (PTP). The clinical benefits of preventing recrudescence (reflecting treatment efficacy) compared with preventing reinfection (reflecting PTP) need further assessment. Antimalarial drug resistance shortens PTP. While blood concentrations are in the terminal elimination phase, the degree of shortening may be estimated from measurements of in-vitro susceptibility and the terminal elimination half-life. More information is needed on PTP following intermittent preventive treatments, and on the relationship between the duration of PTP and immunity, so that policy recommendations can have a firmer evidence base. © 2008 White; licensee BioMed Central Ltd. 2018-07-12T02:31:29Z 2018-07-12T02:31:29Z 2008-03-07 Review Malaria Journal. Vol.7, (2008) 10.1186/1475-2875-7-9 14752875 2-s2.0-40149110041 https://repository.li.mahidol.ac.th/handle/123456789/19357 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=40149110041&origin=inward |
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Slowly eliminated antimalarial drugs suppress malaria reinfections for a period of time determined by the dose, the pharmacokinetic properties of the drug, and the susceptibility of the infecting parasites. This effect is called post-treatment prophylaxis (PTP). The clinical benefits of preventing recrudescence (reflecting treatment efficacy) compared with preventing reinfection (reflecting PTP) need further assessment. Antimalarial drug resistance shortens PTP. While blood concentrations are in the terminal elimination phase, the degree of shortening may be estimated from measurements of in-vitro susceptibility and the terminal elimination half-life. More information is needed on PTP following intermittent preventive treatments, and on the relationship between the duration of PTP and immunity, so that policy recommendations can have a firmer evidence base. © 2008 White; licensee BioMed Central Ltd. |
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How antimalarial drug resistance affects post-treatment prophylaxis |
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