Antimalarial dosing regimens and drug resistance
The contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates. This h...
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th-mahidol.193672018-07-12T09:45:53Z Antimalarial dosing regimens and drug resistance Karen I. Barnes William M. Watkins Nicholas J. White University of Cape Town Nuffield Department of Clinical Medicine Mahidol University Immunology and Microbiology Medicine The contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates. This has been attributed previously to lower immunity, although blood concentrations of many antimalarial drugs are significantly lower in pregnant women and young children than in non-pregnant adults. Nevertheless, there have been no studies of higher dosages. Sub-therapeutic concentrations will certainly contribute to poorer responses to treatment and will fuel the emergence and spread of antimalarial drug resistance. There is an urgent need for studies to optimise antimalarial dosage regimens in infants, young children and pregnant women, both to improve cure rates and to prolong the useful therapeutic lives of antimalarial drugs. © 2008 Elsevier Ltd. All rights reserved. 2018-07-12T02:31:44Z 2018-07-12T02:31:44Z 2008-03-01 Review Trends in Parasitology. Vol.24, No.3 (2008), 127-134 10.1016/j.pt.2007.11.008 14714922 2-s2.0-39749193827 https://repository.li.mahidol.ac.th/handle/123456789/19367 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=39749193827&origin=inward |
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Immunology and Microbiology Medicine Karen I. Barnes William M. Watkins Nicholas J. White Antimalarial dosing regimens and drug resistance |
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The contribution of underdosing to antimalarial treatment failure has been underappreciated. Most recommended dosage regimens are based on studies in non-pregnant adult patients. Young children and pregnant women, who bear the heaviest malaria burden, have the highest treatment failure rates. This has been attributed previously to lower immunity, although blood concentrations of many antimalarial drugs are significantly lower in pregnant women and young children than in non-pregnant adults. Nevertheless, there have been no studies of higher dosages. Sub-therapeutic concentrations will certainly contribute to poorer responses to treatment and will fuel the emergence and spread of antimalarial drug resistance. There is an urgent need for studies to optimise antimalarial dosage regimens in infants, young children and pregnant women, both to improve cure rates and to prolong the useful therapeutic lives of antimalarial drugs. © 2008 Elsevier Ltd. All rights reserved. |
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University of Cape Town |
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University of Cape Town Karen I. Barnes William M. Watkins Nicholas J. White |
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Review |
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Karen I. Barnes William M. Watkins Nicholas J. White |
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Karen I. Barnes |
title |
Antimalarial dosing regimens and drug resistance |
title_short |
Antimalarial dosing regimens and drug resistance |
title_full |
Antimalarial dosing regimens and drug resistance |
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Antimalarial dosing regimens and drug resistance |
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Antimalarial dosing regimens and drug resistance |
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antimalarial dosing regimens and drug resistance |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/19367 |
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